Journal article
The 9-Fluorenylmethoxycarbonyl (Fmoc) group in chemical peptide synthesis-its past, present, and future
W Li, NM O'Brien-Simpson, MA Hossain, JD Wade
Australian Journal of Chemistry | CSIRO PUBLISHING | Published : 2020
DOI: 10.1071/CH19427
Abstract
The chemical formation of the peptide bond has long fascinated and challenged organic chemists. It requires not only the activation of the carboxyl group of an amino acid but also the protection of the Nα-amino group. The more than a century of continuous development of ever-improved protecting group chemistry has been married to dramatic advances in the chemical synthesis of peptides that, itself, was substantially enhanced by the development of solid-phase peptide synthesis by R. B. Merrifield in the 1960s. While the latter technology has continued to undergo further refinement and improvement in both its chemistry and automation, the development of the base-labile 9-fluorenylmethoxycarbon..
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Awarded by Australian Research Council
Funding Acknowledgements
The National Health and Medical Research Council (NHMRC) of Australia and Australian Research Council (ARC) are thanked for financial support over many years for the peptide chemistry and chemical biology studies reported in the authors' laboratories. WL is the recipient of the 2019 Weary Dunlop Foundation grant of the University of Melbourne. JDW is an NHMRC Principal Research Fellow (project numbers APP628404 and 1117483). NMOBS is the recipient of NHMRC funding (project numbers APP1142472, APP1158841), Cancer Council of Victoria funding (project number APP1163285), and Australian Dental Research Foundation Funding in antimicrobial materials. Research at The Florey Institute of Neuroscience and Mental Health is supported by the Victorian Government Operational Infrastructure Support Program. The authors salute Professor Paul Alewood's many years of outstanding collaboration and friendship and wish him well in his retirement.